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Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course

Objectives. To determine the utility of single-stranded conformation polymorphism (SSCP) analysis for mutation screening in the BTK (Bruton's tyrosine kinase) gene, we investigated 56 X-linked agammaglobulinemia (XLA) families. To obtain genotype/ phenotype correlations, predicted protein aberrations were correlated with the clinical course of the disease. Patients. This study included 56 patients

Ornithine metabolism along the female mouse nephron: localization of ornithine decarboxylase and ornithine aminotransferase

The fate of ornithine in the nephron of the female OF-1 Swiss mouse remains unknown. The aim of the present study was to identify the nephron segments containing the key enzymes involved in ornithine metabolism: ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT). Viable tubules isolated by microdissection were incubated with [1-14C]ornithine to study the oxidative pathway. Other tu

Validation of the Brush Model towards VTI-measurement data recorded in Arjeplog 2006

The report shows a validation of the brush tire-model towards measurement data performed in the RFE-project within the IVSS-framework. The data is recorded by VTI at Colmis Proving Ground in Arjeplog. The winter tire, Continental ContiWinterContact TS810 215/55R16, the summer tire, Continental ContiSportContact 225/45R17 91W, and the studded tire: Gislaved Nordfrost 3 215/55R16 are tested longitud

Norms and legal rules : An investigation of the tunnel construction through the Hallandsås ridge

Popular Abstract in Swedish Tunnelbygget genom Hallandsåsen har utvecklats på ett sådant sätt och fått sådana konsekvenser, att frågan hur projektet skall förstås och förklaras är viktig. Vill man studera vilka mekanismer i samhället som kan förhindra projektets förlopp eller dess konsekvenser, bör man först förstå projektet. Matthias Baiers bok handlar om hur man med normer kan förstå och beskrivIn 1992 Swedens biggest tunnelproject begun. Two 8.5 km tunnels should cross a big ridge in southern Sweden which was seen as an obstacle to a fast and efficient railway line connecting Oslo and Gothenburg with Malmö and Copenhagen. However, the project had to stop in 1997 due to environmental damages. With only a third of the tunnel accomplished, the project was also much delayed and had a heavy

Two new species of Allodia subgenus Brachycampta Winnertz from Norway and Sweden (Diptera : Mycetophilidae)

Allodia (Brachycampta) huggerti sp. n. from Sweden and Allodia (Brachycampta) rindeni sp. n. from Norway and Sweden are described based on a few adult males. Detailed illustrations of their terminalia are provided. The A. (B.) barbata species group is defined for species of which both dorsal and ventral branches of the male gonostylus are reduced to slender lobes, and the two new species both belo

Christian Ethics and the Moral Psychologies

Browning offers rich information on theories in current moral psychology. He criticizes these theories and states the superiority of the Christian narrative for the understanding and grounding of morality. This short text is a critical comment to his standpoint.

Social network, social support and the rate of decline of CD4 lymphocytes in asymptomatic HIV-positive homosexual men.

AIMS: To test a stress-disease hypothesis by investigating the influence of social network and social support factors on the course over time of the CD4 lymphocytes in an HIV-positive population of gay men. METHODS: The study is a prospective cohort study of a representative population of HIV-positive gay men, undertaken at the Department of Infectious Diseases, Malmö University Hospital. This is

En essä om estetisk efterrättelse

Popular Abstract in Swedish Meads centrala påstående var att medvetandet uppstår mellan människor. Det individuella subjektet framträder därmed som en effekt. Jag har lyft fram det faktum att Miget ? agenten snarare än subjektet ? föregår och ingår i den sociala interaktionen. I och med det föregår Miget subjekt/objekt distinktionen vilken blir relevant först när interaktionen är en realitet. Den This thesis is about aesthetic observance. By these terms I intend to give an account of a social phenomenon considered an angle of approach on the understanding of norms. I narrow down the problems with the perspective from social psychology. The central claim by George Herbert Mead was that mind arises from human interaction. The individual subject by this means appears as an effect. I whish to

Neural network models of haptic shape perception

Three different models of tactile shape perception inspired by the human haptic system were tested using an 8 d.o.f. robot hand with 45 tactile sensors. One model is based on the tensor product of different proprioceptive and tactile signals and a self-organizing map (SOM). The two other models replace the tensor product operation with a novel self-organizing neural network, the Tensor-Multiple Pe

Compliance and diameter in the human abdominal aorta--the influence of age and sex

OBJECTIVES. Females develop cardiovascular diseases and abdominal aortic aneurysms later in life than males. In this study we investigated the diameter and compliance of the distal abdominal aorta in healthy females of varying ages. The results were compared with those obtained previously from healthy males in order to assess potential sex-related differences in the aging process of the abdominal

Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells

A key question for understanding the mechanisms of pulsatile insulin release is how the underlying beta-cell oscillations of the cytoplasmic Ca2+ concentration ([Ca2+](i)) are synchronized within and among the islets in the pancreas. Nitric oxide has been proposed to coordinate the activity of the beta-cells by precipitating transients of [Ca2+](i). Comparing ob/ob mice and lean controls, we have

Acoustically driven emission of light in granular and layered semiconductors: recent advances and future prospects

Acoustic driving techniques can produce luminescence in semiconductors quite efficiently. A mixture of grain particles, for example, emits light when driven by sufficiently intense acoustic fields. This effect is therefore particularly interesting for exploring the dynamics of granular solids. By applying this novel technique, further insight is gained when monitoring the driving-induced evolution

Kinetics of Oxygen Transfer Reactions Involving Molybdenum Dithiolene Complexes

Oxo transfer reactions from [MoO2(mnt)2]2– [mnt2– = 2,3-disulfanylmaleonitrile dianion (1,2-dicyanoethylenedithiolate)] to the abiological oxygen acceptors PPh3–xEtx (x = 0–3) have been studied spectrophotometrically in acetonitrile. The pseudo-first-order rate constants depend linearly on the concentration of the oxo acceptors. The sequence of reactivity is PEt3 > PEt2Ph > PEtPh2 > PPh3, reflecti

Modeling the effects of knots in Structural Timber

The main purpose of the pursued research is to increase knowledge of the effects of knots in structural timber so that characteristics of weaker timber may be determined and applied to improve current grading techniques. In the process, a three-dimensional fiber paradigm was established, which describes variations of local principle material axes in timber containing knots. The adaptability of the