Human embryonic skin fibroblasts were pretreated with transforming growth factor-beta (TGF-beta) for 6 h and then labeled with [35S]sulphate and [3H]leucine for 24 h. Radiolabeled proteoglycans from the culture medium and the cell layer were isolated and separated by isopycnic density-gradient centrifugation, followed by gel, ion-exchange and hydrophobic-interaction chromatography. The major prote

The development of multicellular organisms is associated with extensive rearrangements of cells and tissues. The driving force for these rearrangements is generated by the cell's actin cytoskeleton. During many morphogenetic processes dynamic rearrangement of the actin cytoskeleton is regulated by small GTPases of the Rho-family. These GTPases are highly conserved throughout the animal kingdom and

The importance ascribed to knowledge externalities for understanding the spatial organization of industries (i.e. clustering) is increasingly being exposed to critical theoretical and empirical scrutiny. This research has not yet spilled over into studies of creative industries. This paper is concerned with reducing this omission by making an empirically based assessment of the importance of respe

Background and aim: Malnutrition in nursing home residents is an important clinical and public health problem. Knowledge is lacking about the reproducibility of dietary recording in geriatric patients. Few studies have described water intake in this age group. The aim of this study was to test the reproducibility of a 7-day dietary record routine in a clinical setting. Methods: The dietary intake

Aim: To investigate the anatomical and functional results and the complications in eyes operated on using vitrectomy without scleral buckling for all forms of rhegmatogenous retinal detachment ( RRD). Methods: All cases of primary RRD at the University Hospital of Lund, Lund, Sweden, treated by one surgeon during a period of 3 years were retrospectively reviewed. In 131 ( 98%) of 134 consecutive c

Background. In a search for immunosuppressive drugs having novel mechanisms, monocarboxylate transporter (MCT-1) inhibitors were identified that markedly inhibited immune responses. Here, we report the effects of AR-C117977, a potent MCT-1 inhibitor, on alloimmune responses in the rat. Methods. In vitro activity was determined in a rat mixed lymphocyte response (MLR). In vivo activity was tested i

The aim of this study was to assess the agreement between observers analyzing activity patterns during truck engine assembly work based on video recordings. Two observers observed the recordings of nine workers, on the average 2.2 h long, assigning activities to four activity categories. For each activity category data were obtained on the mean duration of uninterrupted sequences of activities and

Popular Abstract in Swedish Begreppet social rörlese är ett centralt sociologiskt begrepp. Trots det finns det en rad olika sätt att definiera detta begrepp. Avhandlingen söker svara på frågan vad begreppet social rörelse "betyder". För att svara på den frågan utgår författaren från en arbetsdefinition och en rad dimensioner av begreppet. Via en läsning av begreppets teoretiska utveckling söker föThis thesis develops the concept formation of 'social movement'. The author stresses the importance of the inherent classical understanding of the concept as defining a collective actor involved in a struggle regarding main social and cultural trends in society. The concept of social movement is treated as having been an unclear concept. The author therefore formulates a working definition that al

Sequential isolates from eight cynomolgus monkeys experimentally infected with Simian immunodeficiency virus (SIVsm, of sooty mangabey origin) were tested for coreceptor use in the human osteosarcoma indicator cell line, GHOST(3), expressing CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, BOB, or the orphan receptor Bonzo. The indicator cell line carries the human immunodefici

Various normative decision theories are discussed in the context of fire risk management. A method suitable for practical decision making in respect to fire safety investments is presented and exemplified. The method involves the use of second-order probabilities to represent uncertainty regarding probability values. A discussion on the use of Bayes theorem in combination with decision analysis is

Neural stem cells in the subventricular zone of adult rodents produce new striatal neurons that may replace those that have died after stroke; however, the neurogenic response has been considered acute and transient, yielding only small numbers of neurons. In contrast, we show herein that striatal neuroblasts are generated without decline at least for 4 months after stroke in adult rats. Neuroblas

An extensive sampling programme has been conducted in six test cells since 1989. The test cells are located at the Spillepeng landfill in the City of Malmo in southern Sweden. Each test cell received a specific waste composition. The main objective of the project was to evaluate the dependence of biogas production on landfill waste composition. Methane production rates in test cells with high amou

Background When using Health-Related Quality of Life (HRQoL) in assessing outcomes of treatment, normative data for different diagnoses are needed to allow cross-comparisons of existing and future studies. We determined the SF-36 scores in patients with surgical lumbar spine problems. Methods This is a prospective observational study of consecutive surgical patients in one institution. In additi

Metallo-beta-lactamases are bacterial enzymes that may function with either one or two zinc ions bound in the active site. In this work, the binding of benzylpenicillin to mono-zinc metallo-beta-lactamase from Bacillus cereus has been investigated in a docking procedure applying a combined quantum mechanical/molecular mechanical method as the final step. It is demonstrated that the substrate can b