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3D non-LTE modeling of the stellar center-To-limb variation for transmission spectroscopy studies

Context. Transmission spectroscopy is one of the most powerful techniques used to characterize transiting exoplanets, since it allows for the abundance of the atomic and molecular species in the planetary atmosphere to be measured. However, stellar lines may bias the determination of such abundances if their center-To-limb variations (CLVs) are not properly accounted for. Aims. This paper aims to

EDGE – Dark matter or astrophysics? Breaking dark matter heating degeneracies with H I rotation in faint dwarf galaxies

Low-mass dwarf galaxies are expected to reside within dark matter haloes that have a pristine, ‘cuspy’ density profile within their stellar half-light radii. This is because they form too few stars to significantly drive dark matter heating through supernova-driven outflows. Here, we study such simulated faint systems (104 ≤ M* ≤ 2 × 106 M) drawn from high-resolution (3 pc) cosmological simulation

Integrative Kinase Activity Profiling and Phosphoproteomics of rd10 Mouse Retina during cGMP-Dependent Retinal Degeneration

Inherited retinal degenerative diseases (IRDs) are a group of rare diseases that lead to a progressive loss of photoreceptor cells and, ultimately, blindness. The overactivation of cGMP-dependent protein kinase G (PKG), one of the key effectors of cGMP-signaling, was previously found to be involved in photoreceptor cell death and was studied in murine IRD models to elucidate the pathophysiology of

Analysis of vitamin D and its metabolites in biological samples – Part II : Optimization of a sample preparation method for liver tissue

Extraction of vitamin D, including its hydroxylated and esterified metabolites, from soft tissues such as the liver is challenging due to the lipophilic character of matrix and analytes that are expected in very low concentration levels. In this study, we aimed at the optimization of two-step extraction using solid–liquid extraction as the first step, followed by solid-phase extraction. Various so

Kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy based on multiple small VOIs

Purpose: The aim was to investigate the use of multiple small VOIs for kidney dosimetry in [177Lu]Lu-DOTA-TATE therapy. Method: The study was based on patient and simulated SPECT images in anthropomorphic geometries. Images were reconstructed using two reconstruction programs (local LundaDose and commercial Hermia) using OS-EM with and without resolution recovery (RR). Five small VOIs were placed

Food Safety 4.0

Food Safety 4.0 is a term derived from Industry 4.0 that focuses on all aspects of food safety management based on cyber-physical systems. The premise of Food Safety 4.0 is that real-time information and the interconnectivity of things, complemented by novel technologies, will revolutionize the way food safety is managed. There is enormous potential in terms of advancing product traceability, dete

High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer

In normal colon tissue, oestrogen receptor alpha (ERα) is expressed at low levels, while oestrogen receptor beta (ERβ) is considered the dominant subtype. However, in colon carcinomas, the ERα/β ratio is often increased, an observation that prompted us to further investigate ERα’s role in colorectal cancer (CRC). Here, we assessed ERα nuclear expression in 351 CRC patients. Among them, 119 exhibit

Analysis of vitamin D and its metabolites in biological samples – Part I : Optimization and comparison of UHPSFC-MS/MS and UHPLC-MS/MS methods

Fat-soluble vitamin D is an essential bioactive compound important for human health. Insufficient vitamin D levels can result not only in bone disease but also in other disorders, such as cancer, metabolic disorders, and diseases related to poor immune function. The current methods commonly used for vitamin D analysis are often applied to determine the levels of the most abundant metabolite in pla

Orthostatic hypotension is associated with higher levels of circulating endostatin

AimsThe pathophysiology of orthostatic hypotension (OH), a common clinical condition, associated with adverse outcomes, is incompletely understood. We examined the relationship between OH and circulating endostatin, an endogenous angiogenesis inhibitor with antitumor effects proposed to be involved in blood pressure (BP) regulation.MethodsWe compared endostatin levels in 146 patients with OH and 1

Halide Engineering in Mixed Halide Perovskite-Inspired Cu2AgBiI6 for Solar Cells with Enhanced Performance

Cu2AgBiI6 (CABI) is a promising perovskite-inspired absorber for solar cells due to its direct band gap and high absorption coefficient. However, the nonradiative recombination caused by the high extrinsic trap density limits the performance of CABI-based solar cells. In this work, we employ halide engineering by doping bromide anions (Br–) in CABI thin films, in turn significantly improving t

Halide Perovskites for Photoelectrochemical Water Splitting and CO2 Reduction: Challenges and Opportunities

Photoelectrochemical water splitting and CO2 reduction provide an attractive route to produce solar fuels while reducing the level of CO2 emissions. Metal halide perovskites (MHPs) have been extensively studied for this purpose in recent years due to their suitable optoelectronic properties. In this review, we survey the recent achievements in the field. After a brief introduction to photoelectroc

Children’s Voices on the COVID-19 Pandemic as Presented in Swedish Junior and Daily Newspapers

This study focuses on children’s voices as they were presented in Swedish newspapers during the COVID-19 pandemic. It explores the ways in which journalists featured children’s experiences of everyday life during a time of crisis. A descriptive, thematic text analysis of 83 articles resulted in four prominent themes: children’s voices as a mouthpiece for or against school closure, children as cocr

The First Swedish Outbreak with VIM-2-Producing Pseudomonas aeruginosa, Occurring between 2006 and 2007, Was Probably Due to Contaminated Hospital Sinks

Multidrug-resistant Pseudomonas aeruginosa is an increasing clinical problem worldwide. The aim of this study was to describe the first outbreak of a Verona integron-borne metallo-ß-lactamase (VIM)-2-producing P. aeruginosa strain in Sweden and its expansion in the region. A cluster of multidrug-resistant P. aeruginosa appeared at two neighbouring hospitals in 2006. The isolates were characterized

Enabling Methodologies for Renewable and Sustainable Energy

This book aims to provide practical aspects of, and an introduction to, the applications of various technological advancement tools, such as AI, machine learning to design, big data, cloud computing, and IoT, to model, characterize, optimize, forecast, and do performance prediction of renewable energy exploitation. It further discusses new avenues for energy sources such as hydrogen energy generat

Osäker framtid för riktade ränteavdragsregler – En analys av mål HFD 2024 ref. 6

Den 22 januari 2024 meddelade Högsta förvaltningsdomstolen dom i ännu ett mål avseende de riktade ränteavdragsbegränsningsreglerna. Skatterättsnämnden hade i ett förhandsbesked tidigare slagit fast att även 24 kap. 19 § första stycket IL var oförenlig med etableringsfriheten, vilket nu även bekräftas av Högsta förvaltningsdomstolen med stöd av argumentationen i Lexel-målet. Detta avgörande innebär

Liquid-liquid phase separation (LLPS) in DNA and chromatin systems from the perspective of colloid physical chemistry

DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids. The process of DNA phase separation induced by positively charged species is often called DNA condensation. Generally, it refers to either intramolecular DNA compaction (coil-globule transition) or intermolecular D

Numerical study on train-induced vibrations : A comparison of timber and concrete buildings

This paper deals with the prediction of train-induced building vibrations by using a numerical framework. The framework is based on a sub-structure approach, where a sequence of different models are used. The free-field ground vibrations and the track receptance are calculated using 2.5D technique where the railway track is represented by finite elements that couple to a dynamic stiffness of the u