Small heat-shock protein chaperones are important players in the protein quality control system of the cell, because they can immediately respond to partially unfolded proteins, thereby protecting the cell from harmful aggregates. The small heat-shock proteins can form large polydisperse oligomers that are exceptionally dynamic, which is implicated in their function of protecting substrate protein

Popular Abstract in Swedish Mellanörats funktion är att överföra och förstärka ljudvågor från luften i hörselgången till innerörats vätska. Denna överföring är optimal när trumhinnan är i neutral position, dvs när trycket i mellanörat och omgivningen är lika. Avvikelser i mellanörats tryck ses vid kroniska mellanöresjukdomar, fr a är det visat ett samband mellan negativt tryck och sjukdomstillstånThe middle ear (ME) pressure is regulated by gas diffusion over the ME mucosa and pressure equalizations via the Eustachian tube (ET). Disturbance in the regulation of ME pressure is believed to contribute to the development of chronic ear diseases. In this work subjects with chronic central perforation (CCP), healthy ears with ventilation tubes (VTs), attic cholesteatoma (AC) and Meniere’s diseas

High-spin states in Tl-198 were studied using the Au-197(alpha, 3n) reaction. The level scheme was considerably extended including two new bands and several non-yrast levels. One of the new bands is possibly a chiral partner to the yrast pi h(9/2) circle times vi(13/2)(-1) band. Two-quasiparticle-plus-triaxial-rotor model calculations suggest an aplanar orientation of the total angular momenta for

Multiexciton absorption cross sections are important for analysis of a number of experiments, including multiple exciton generation and stimulated emisson. We present a rigorous method to determine these cross sections using transient absorption (TA) measurements. We apply the method to CdSe quantum dots (QDs) and core–shell (CdSe)ZnS QDs. The method involves measuring TA dynamics for various exci

Esophageal dysmotility and gastroparesis are common secondary complications in patients with diabetes mellitus. Patients with dysmotility express antibodies against gonadotropin-releasing hormone (GnRH) in serum. The aim of the present study was to scrutinize patients with diabetes mellitus with regard to the presence of GnRH antibodies, and to examine associations between antibodies and clinical

Two exposures in Jylland, Denmark, encompassing beds of latest Oligocene to earliest Miocene age (latest Chattian-early Aquitanian) yielded well-preserved palynofloras. The assemblages indicate that Jylland was covered by extensive Taxodiaceae swamp forests in the mid-Cenozoic. Besides a Taxodiaceae-Cupressaceae association, which was overwhelmingly dominant, other common plants in this habitat we

Context: The diagnosis of and reporting parameters for prostate cancer (PCa) have evolved over time, yet they remain key components in predicting clinical outcomes. Objective: Update pathology reporting standards for PCa. Evidence acquisition: A thorough literature review was performed for articles discussing PCa handling, grading, staging, and reporting published as of September 15, 2011. Electro

Background: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of neutralizing antibodies is therefore of primary importance, but is hampered by the fact that we do not know which assay(s) can provide measures of protective immu

Forests are important from many perspectives. Forestry delivers products such as timber, fiber and fuel; forests are also important for recreational activities as well as for the global carbon balance. Consequently, it is important to develop methods that enable efficient monitoring of disturbances, such as insect attacks, over vast forested areas. These methods can be based on remote sensing, sin

We sought to propose and test the validity of a comprehensive prognostic model in middle cerebral artery-stroke treated with Intravenous thrombolysis. A total of 127 consecutive patients (aged 70 +/- 12 years; 54% males) were included in this retrospective study. Variables included in our prognostic model were: NIHSS on admission (1-3 points), occurrence of hyperdense middle cerebral artery sign a

Partial correction of anemia in patients with chronic kidney disease (CKD) reduces left ventricular hypertrophy (LVH), which is a risk factor for cardiovascular (CV) morbidity, but complete correction of anemia does not improve CV outcomes. Whether LV geometry associates with CV events in patients who are treated to different hemoglobin (Hb) targets is unknown. One of the larger trials to study th

Abstract in UndeterminedThe MAX IV facility presently under construction will include two storage rings for the production of synchrotron radiation. Both rings will be operated at a constant 500 mA of stored current with top-up shots supplied by the MAX IV linac acting as a full-energy injector. Until recently, injection into both storage rings was designed using a conventional approach: a closed

A decade has passed since the first human embryonic stem cell (hESC) line was established, providing immense hope in curing diseases by cell replacement therapy. For instance, in the pancreas, the insulin-producing β-cells are damaged in diabetes patients, and a successful replacement of those cells could provide a cure. These cells can be replaced by organ donation, but owing to a profound scarci

BACKGROUND: Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. However, symptomatic cases have been described, e.g. tumours, particularly pituitary adenomas, malformations, and infections/inflammations. The evaluation of cluster headache is an issue unresolved. CASE DESCRIPTION: We present a case of a 43-year-old patient who presented with

Background: Family size and birth order are known to influence the risk of some cancers. However, it is still unknown whether these effects change from early to later adulthood. We used the data of the Swedish Family Cancer Database to further analyze these effects. Methods: We selected over 5.7 million offspring with identified parents but no parental cancer. We estimated the effect of birth orde