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Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Apparent increase in frontal cortex water T2 in aged individuals with progressive multiple sclerosis stabilizes in biexponential model constrained by tissue partial volumes

Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when an

Remembering Ross Leadbetter: some personal reflections

Ross Leadbetter had had a broad and deep influence on the development of proba-bilistic and statistical theory of extreme values and on the application of extreme-value methods. He has been an inspiration and a friend for many of us. This edito-rial collects thirteen personal recollections of Ross and his work. An account of hiscareer and some of his work can be found in the IMS Obituary “Ross Lea

Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Cross-sectional assessment of frontal-cortex glutathione, GABA, and glutamate in individuals with relapsing-remitting and progressive multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease that damages the central nervous system and affects an estimated 2.3 million people worldwide. One potential key to understanding MS is investigating the metabolic distinctions between its relapsing-remitting (RR-MS) and progressive courses (P-MS). We obtained single-voxel metabolic 1H spectra at 7 Tesla from the frontal cortex of RR-MS and P-MS pat

7. In vivo quantification of glutathione T2 in the human brain at 7 Tesla using echo time extension with variable refocusing selectivity and symmetry

The tripeptide glutathione (L-γ-glutamyl-L-cysteinyl glycine or GSH) is an endogenous antioxidant implicated in many neurological conditions, including multiple sclerosis. Its precise quantification by proton magnetic resonance spectroscopy is, however, hampered by its uncertain T2. Here, we present a method for the quantification of GSH T2 in the human brain at 7 Tesla using optimized echo time e

A systematic discrepancy between the short circuit current and the integrated quantum efficiency in perovskite solar cells

Halide perovskites solar cells are now approaching commercialisation. In this transition from academic research towards industrialisation, standardized testing protocols and reliable dissemination of performance metrics are crucial. In this study, we analyze data from over 16,000 publications in the Perovskite Database to investigate the assumed equality between the integrated external quantum eff

IMAGINE sustainability : integrated inner-outer transformation in research, education and practice

There has been a recent proliferation of research and practice on the interior dimensions of sustainability, such as values, beliefs, worldviews and inner capacities. This nascent field of inner transformation is dynamic and emerging, with varied terminology, a breadth of applications, and intense debate about possible contributions as well as limitations and shortcomings. In this article, we aim

Vad våra inre liv har med klimatkrisen att göra

Vår forskning visar på att klimatkrisen inte är en kris i det yttre, utan snarare en inre relationskris. Den drivs av växelspelet mellan vårt inre liv och klimat-förändringarna, vilket i nuläget försämrar både det personliga och planetära välbefinnandet. Detta växelspel demonstrerar att våra inre liv inte bara är offer för den ökande klimatpåverkan. Det är också en viktig drivkraft bakom klimatkri

Circular Business Models for the Solar Power Industry - Guide for Policy Makers

Solar power and electric vehicles (EV) are set to play a leading role in the achievement of the 2030 EU renewable targets and the commitment to carbon neutrality by 2050. Importantly, solar photovoltaics (PV), in combination with energy storage, also has the potential to significantly enhance European energy security, provide citizens and industry with competitive energy, and lead to the creation

Geospatial mapping of surgical systems for earthquake emergency planning in Guerrero, Mexico : an ecological study

BACKGROUND: Accessibility to surgical services can impact earthquake preparedness and response. We aimed to estimate the population with timely access to surgical care in Guerrero, a Mexican state with high tectonic activity, and identify populations at risk in the event of an earthquake.METHODS: We conducted an ecological study using open government data. We extracted data from Guerrero municipal

Circular business model innovation : A guidebook for practitioners

The purpose of this booklet is to offer easy-to-use guidelines for businesses to design and implement circularity strategies into their business model. Specifically, the booklet will provide step-by-step guidance on how to ideate, design, test, and scale novel circular business models. For each stage of this circular business model innovation (CBMI) process a selection of tools and methods will be

Towards a circular solar power sector: Experience with a support framework for business model innovation

The rapid expansion of the global solar photovoltaic (PV) market as part of the transition to a low-carbon energy future will increase both demand for raw materials used in PV product manufacturing as well as future PV panel waste volumes. There is an urgent need for solar industry businesses to adopt circular business models, and to support this process through targeted tools and methods that can

Experiments to identify new business models

This report compiles the findings of two business experiment surveys, conducted under CIRCUSOL Task 2.4. The experiments investigated customer preferences for two relatively novel market segments for circular photovoltaics, specifically (1) solar-powered charging stations for shared micro-mobility services, and (2) PV-systems for home-charging of electric vehicles. The experiments used the method

Initial version of CBMD framework and co-creation process approach

This report compiles the findings concerning the “Initial version of CBMD framework and co-creation process approach”, hereafter be referred to as “circular product-service system innovation support method” (cPSS method). The report has been compiled from an extensive review of the literature from a variety of inter-related academic research fields, including business model theory, product service

Hard-to-reach energy users : An ex-post cross-country assessment of behavioural-oriented interventions

Hard-to-reach (HTR) energy users encompass individuals who are physically difficult to reach, underserved, or challenging to engage and motivate in demand-side energy programmes. Given a mix of societal challenges (e.g. inequity, energy poverty, decarbonisation, the COVID-19 pandemic), HTR energy users are receiving increasing attention. However, there is a lack of knowledge on the performance of

Energy communities as accelerators of energy transition in cities

The European Green Deal states that greenhouse gas (GHG) emissions should be reduced by at least 50% by 2030, and that there should be no net GHG emissions by 2050. The energy sector is a key in this transformation, and energy communities can as accelerators of transitionsKey findings:•Future scenarios outline a decentralized energy system in which smaller generation units have become more economi