This paper addresses the concept of an intergenerational contract. Due to its various and/or imprecise definitions, the intergenerational contract seems a vague and descriptive notion with limited analytical relevance. Is it a contract based on kinship or a contract between age groups? Does it refer to implicit and informal obligations, or explicit and formal ones as well? The author discusses the

There is increasing evidence that reactive oxygen species (ROS), a group of unstable and highly reactive chemical molecules, play a key role in regulating and maintaining life-history trade-offs. Upregulation of ROS in association with immune activation is costly because it may result in an imbalance between pro- and antioxidants and, hence, oxidative damage. Previous research aimed at quantifying

As policy and theory travel, comparative urbanism becomes important to address questions concerning if and how gentrification and revanchist urbanism have ‘gone South’, or ‘gone East’. In recent decades, Taipei has experienced a shift in economic base, massive urban renewal, neoliberal reforms and associated social polarisation. In this paper we ask to what extent gentrification and revanchist urb

Apart from glucose, proteins and lipids also stimulate incretin and islet hormone secretion. However, the glucoregulatory effect of macronutrients in combination is poorly understood. We therefore developed an oral mixed meal model in mice to 1) explore the glucagon-like peptide-1 (GLP-1) and islet hormone responses to mixed meal versus isocaloric glucose, and 2) characterize the relative contribu

Purpose The aim of this study was to examine the incidence of musculoskeletal injuries, site and type of injury, and the most common injury diagnoses in young ballet dancers at the Royal Swedish Ballet School, a public school in Stockholm. Methods This retrospective study of 476 students (297 girls and 179 boys) aged 10-21 years was based on medical records for the period August 1988 to June 1995.

An optimization procedure has been established aiming to design an integrated thermal protection system (ITPS) with minimum weight. The objective of this research is to establish the procedure and ensure its effectiveness. A corrugated sandwich panel has been chosen as the optimization problem. The ITPS geometric dimensions are considered as the design variables. The objective function is the mass

Long-chain fatty acids (LCFAs) are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks and signaling intermediates. Here we describe how the association of LCFAs to a partially unfolded, extracellular protein can alter the presentation to target cells and cellular effects. HAMLET (Human α-lactalb

Abstract Objective. To study the associations between active choice of primary care provider and healthcare utilization, multimorbidity, age, and sex, comparing data from primary care and all healthcare in a Swedish population. Design. Descriptive cross-sectional study using descriptive analyses including t-test, correlations, and logistic regression modelling in four separate models. Setting and

Hereditary complete deficiency of complement component C1q is associated with a high prevalence of systemic lupus erythematosus and increased susceptibility to severe recurrent infections. An 11-year-old girl was screened for immunodeficiency due to a history of recurrent meningitis and pneumonia. Immunologic studies revealed absence of classic pathway hemolytic activity and undetectable levels of

This work investigates the predictability of seasonal to inter-annual streamflow over several river basins in Norway through the use of multi-model ensembles. As general circulation models (GCMs) do not explicitly simulate streamflow, a statistical link is made between GCM-forecast fields generated in December and average streamflow in the melting season May-June. By using the Climate Predictabili

A physically-based, distributed hydrological model (MIKE SHE) was used to quantify overland runoff in response to four extreme rain events and four types of simulated land use measure in a catchment in Norway. The current land use in the catchment comprises arable lands, forest, urban areas and a stream that passes under a motorway at the catchment outlet. This model simulation study demonstrates

A sophisticated reading of the randomized trial evidence suggests that, although screening for prostate cancer with prostate-specific antigen (PSA) can reduce cancer-specific mortality, it does so at considerable cost in terms of the number of men who need to be screened, biopsied, and treated to prevent one death. The challenge is to design screening programs that maximize benefits (reducing pros

JavaScript is a sequential programming language that has a large potential for parallel execution in Web applications. Thread-level speculation can take advantage of this, but it has a large memory overhead. In this article, we evaluate the effects of adjusting various parameters for thread-level speculation. Our results clearly show that thread-level speculation is a useful technique for taking a

The physical, chemical, and biological properties of nanostructures depend strongly on their geometrical dimensions. Here we present a fast, noninvasive, simple-to-perform, purely optical method that is capable of characterizing nanostructure dimensions over large areas with an accuracy comparable to that of scanning electron microscopy. This far-field method is based on the analysis of unique fin

Health-beneficial effects of adhering to a healthy Nordic diet index have been suggested. However, it has not been examined to what extent the included dietary components are exclusively related to the Nordic countries or if they are part of other European diets as well, suggesting a broader preventive potential. The present study describes the intake of seven a priori defined healthy food items (

Slow and hovering animal flight creates high demands on the lift production of animal wings. Steady state aerodynamics is unable to explain the forces required and the most commonly used mechanism to enhance the lift production is a leading edge vortex (LEV). Although LEVs increase the lift, they come at the cost of high drag. Here we determine the flow above the wing of lesser long-nosed bats at

Over the past decade, the chemistry of low-valent transition metal clusters has again come to the fore, primarily as a result of the development of nanochemistry and the realization that large clusters are on the cusp of the nano-domain. This perspective focuses on these recent developments in low-valent transition metal cluster chemistry, specifically looking at cluster-nanoparticles, the use of

Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substra

Abstract in UndeterminedPrice jumps are mostly related to investor reactions to unexpected extreme news. We perform an event study of price movements after jumps to analyse if investors' reactions are affected by psychological biases. We employ recent non-parametric methods based on intraday returns to separate large price movements that are related to unexpected news from those merely caused by p