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Molecular mechanisms of resistance to Rituximab and pharmacologic strategies for its circumvention.

The introduction of Rituximab has greatly improved therapeutic options for patients with B-cell non-Hodgkin lymphoma (B-NHL). However, a substantial fraction of patients with aggressive B-NHL fails first-line therapy, and most patients with relapsing indolent B-NHL eventually acquire Rituximab resistance. Molecular understanding of the underlying mechanisms facilitates the development of pharmacol

Rätten och den sociosymboliska sömnen - reflektioner om det industriella folkmordets eftereffekter

Combining cultural theory with the philosophy of law, this essay argues that the advent of state-managed, industrial genocide has brought about a crisis of confidence in the institutions of modern society. A wave of incrimination emanates from the holocaust, which primarily strikes against the institutions of law, but also affects the credibility of sociosymbolic mandate as such. Drawing on the wr

The metabolic syndrome and risk of myocardial infarction in familial hypertension (Hypertension Heredity in Malmö Evaluation study).

OBJECTIVES: The aim of this study was to examine whether three main definitions of the metabolic syndrome (MetS) - WHO, National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation - identify the same individuals and are able to predict incident myocardial infarction (MI) in families with essential hypertension. METHODS: The tested definitions were prospec

Betonstrategie für den Oresund-Tunnel

Abstract in German Zur Überwachung der Qualität des Betons für den Oresund-Tunnel wurde eine umfassende Betonspezifikation ausgearbeitet. Die geforderte Lebensdauer des Bauwerks ist mit 1 00 Jahre angesetzt - und dies bei aggressiven, betonangreifenden Umgebungsbedingungen: Meerwasser, Taumittel, Frost-Tau-Wechsel, Wasserdruck usw. Der vorliegende Beitrag gibt Überblick über die wichtigsten AnfordA comprehensive concrete specification has been prepared to control the quality of the concrete for the Øresund Link. The required service life of the structure is 100 years in environmental conditions that are aggressive to concrete ; marine environment deicing agents, freeze-thaw action, water pressure etc. This paper gives a short review of the most important requirements for the concrete to be

Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular disease.

Abstract. Dunér P, To F, Alm R, Gonçalves I, Fredrikson GN, Hedblad B, Berglund G, Nilsson J, Bengtsson E (Malmö University Hospital, Lund University, Lund, Sweden). Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular disease. J Intern Med 2009; doi: 10.1111/j.1365-2796.2008.02067.xObjectives. Accumulation and subsequent oxidation of LDL

Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease.

In Parkinson's disease (PD), the main pathology is a loss of nigrostriatal dopamine (DA) neurons. Clinical trials with intrastriatal transplantation of human embryonic mesencephalic tissue have shown that grafted DA neurons reinnervate the striatum, restore striatal DA release and, in some patients, induce major clinical benefit. Stem cells could provide an unlimited source of DA neurons for trans

CTH17-2: Energy-efficient cooperative relaying over fading channels with simple relay selection

We consider a cooperative wireless network where the source broadcasts data to relays, some or all of which cooperatively beamform to forward the data to the destination. The network is subject to an overall outage constraint. We generalize the standard approaches for cooperative communications in two respects: (i) we explicitly model and factor in the cost of acquiring channel state information (