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During the biosynthesis of chondroitin/dermatan sulfate (CS/ DS), a variable fraction of glucuronic acid is converted to iduronic acid through the activities of two epimerases, dermatan sulfate epimerases 1 (DS-epi1) and 2 (DS-epi2). Previous in vitro studies indicated that without association with other enzymes, DS-epi1 activity produces structures that have only a few adjacent iduronic acid unit

Extracellular histones are present in the airways because of cell death occurring during inflammation. They promote inflammation and cause tissue damage due to their cationic nature. The anionic phosphoglycoprotein osteopontin (OPN) is expressed at high levels during airway inflammation and has been ascribed both pro- and anti-inflammatory roles. In this study, it was hypothesized that OPN may neu

Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA.

Historia i futurum handlar på ett övergripande plan om synen på historieämnet i svensk skola från 1919 till 2011 såsom det kommer till uttryck i styrdokument och lärobokstexter. Den är också en av de första studierna av hur kunskapsutveckling i historia kan uttryckas teoretiskt och hur sådana tankegångar har tillämpats – eller inte tillämpats – på grundskolans och gymnasiets historieämne. I princiFacing an unknown future, the meaning of history is not primarily a fixed set of knowledge about the past, but a well-developed historical consciousness. This is a generic skill, emanating from an understanding of history as something that we are, and at the same time as something that we create. From a historical-cultural perspective, the learning process can be described with a point of departur

Förintelsen är en historisk händelse som lever vidare i samtidens medvetande i form av minnesmonument och museala minnesutställningar och processas av forskningsinstitutioner och myndigheter. Bland överlevandefamiljerna lever minnet kvar och nu har några av deras barnbarn, den Tredje generationens överlevande, tagit på sig att förvalta minnet. Samtidigt florerar antisemitismen i det svensk samhällThe Holocaust is an event that lives on in societies’ consciousness in the form of memorial monuments and museums, and is processed by research institutions and authorities. My own journey began when meeting upper secondary students who denied the Holocaust, and I soon came in contact with a group who identify themselves as Third Generation Survivors; grandchildren of those who survived the Holoca

Background: Lung transplant patients experience a high risk of airway infections and microbial colonization of the lung due to constant exposure to the environment through inhaled microorganisms, denervation, reduced ciliary transport, and decreased cough. Methods: In this nationwide prospective study on Swedish lung transplant patients, we evaluated the microbiological panorama of bacteria, fungi

We examine trends in innovation output for two highly ranked innovative countries: Finland and Sweden (1970-2013). Our novel dataset, collected using the LBIO (literature-based innovation output) method, suggests that the innovation trends are positive for both countries, despite an extended downturn in the 1980s. The findings cast some doubt on the proposition that the current stagnation of many

The subject of this dissertation is the regulation of banks. The enquiry is built around three overreaching research questions:1. What is a bank?2. Why do banks have to be regulated?3. How should banks be regulated? Each of these three questions is dedicated a separate and comprehensive section, each consisting of several chapters. Even though the subject is jurisprudence, the perspective of the

Aims: Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulators sirtuins are affected in HD. Methods: Quantitative real-time polymerase chain reactions were used to assess levels of SIRT1-3 and downstream targets in post mortem brain tissue from HD

Purpose: A cost minimisation analysis compares the costs of different interventions’ to ascertain the least expensive over time. We compared different prostate targeted drug treatments with TURP to identify the optimal cost saving duration of a medical therapy for symptomatic benign prostatic enlargement (BPE). Methods: The Evolution registry is a prospective, multicentre registry, conducted by th

Migration usually consists of intermittent travel and stopovers, the latter being crucially important for individuals to recover and refuel to successfully complete migration. Quantifying how sickness behaviours influence stopovers is crucial for our understanding of migration ecology and how diseases spread. However, little is known about infections in songbirds, which constitute the majority of

Understanding how ecosystem services interact to support crop yield is essential for achieving food security. Here we evaluate the interactions among biotic pest regulation, pollination, and nutrient cycling. We found only 16 studies providing 20 analyses of two-way interactions. These studies show that multiple services limit crop yield simultaneously. Complementary effects (no interactions) betw