Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of p

Research on figurative meaning in Autism Spectrum Disorder (ASD) would benefit from considering a greater variety of data types and using more diverse methods. Previous studies have predominantly applied experimental methods to investigate processing of figurative language (mostly metaphor) and have for the most part concluded that individuals with ASD have deficits in figurative language comprehe

An important assumption when it comes to leader–follower relationships is that compliance and subordination are basically voluntary. In this article, we problematize and develop this assumption and discuss different circumstances in which voluntariness in terms of followership may be compromised. Based on this discussion, we also suggest a tentative model of follower voluntariness, indicating dime

Minnesruna över docent Patrick Meurling (1931-2016) med fokus på dennes insatser som ordförande m m i Fakirensällskapet.

miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5

Föredrag rörande Axel Wallengrens relation till scenkonst och dramatik samt om dennes framförande av sina egna humortexter och senare dramatiseringar av dessa.

An experimental investigation into the micromixing performance of coaxial mixers in a viscous system is reported, in which the iodide-iodate reaction system is chosen to quantitatively characterize the product distributions. The effects of feeding time, feeding position, impeller speed, inner impeller configuration, and operation mode on the segregation index, Xs, are examined. It is revealed that

Languages contain thousands of words each and are made up by a seemingly endless collection of sound combinations. Yet a subsection of these show clear signs of corresponding word shapes for the same meanings which is generally known as vocal iconicity and sound symbolism. This dissertation explores the boundaries of sound symbolism in the lexicon from typological, functional and evolutionary pers

Background: The BREATHE study is a cross-sectional study of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities and combinations of obstructive airway disease. Design: Patients with suspicion of asthma and/or COPD and healthy controls were invited to participate in the study and had a standard evaluation performed consisting of questi

This research investigated the congruence between the ideologies of political parties and the ideological preferences (N = 1515), moral intuitions (N = 1048), and political values and worldviews (N = 1345) of diverse samples of Swedish adults who voted or intended to vote for the parties. Logistic regression analyses yielded support for a series of hypotheses about variations in ideology beyond th

Aim: There is a lack of authorised medicines for paediatric patients and improved drug development is necessary. The aim of this study was to evaluate the need for infrastructure and support for paediatric clinical trials in Sweden. Methods: A web-based survey was sent to doctors and nurses involved in the care of neonates, children and adolescents assessing the current situation and future needs

Immune checkpoint inhibitors (ICIs) have received much attention not least for melanoma since the award of the Nobel prize in 2018. Here, we review the current state of knowledge about the use of these monoclonal antibodies (mAbs) in non-small cell lung cancer (NSCLC). These drugs have generally been conditionally approved on limited early data and there are few long-term follow-up data from rando

This study is carried out by using numerical simulations to investigate the effect of target surface curvature and the nozzle-to-target surface distance on the flow structure and heat transfer characteristics in a pin-finned double-wall cooling structure. The flow is directly impinging on the target surface and is disturbed by the pin fins, and then released from the film holes after passing the d

Introduction: Developing a national assistive products list is an important part of an assistive technology policy and requires knowledge of total population need, and product costs and benefits; information is not always readily available in low-income countries. Our experience in Tajikistan of developing a national assistive products list provides guidance for others. Methods: Two hundred people

Introduction: Reaching universal coverage of assistive technologies remains a challenge in many low- and middle-income countries. Tajikistan has recently adopted several policies and national strategies to strengthen the rights of people with disabilities and improve the provision of assistive products. However, Tajikistan faces a number of challenges, including ensuring sustainable funding for th

Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. The aims of the studies conducted in this thesis were to contribute to the kn

Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable