Microarray-based gene expression analysis holds promise of improving prognostication and treatment decisions for breast cancer patients. However, the heterogeneity of breast cancer emphasizes the need for validation of prognostic gene signatures in larger sample sets stratified into relevant subgroups. Here, we describe a multifunctional user-friendly online tool, GOBO (http://co.bmc.lu.se/gobo),

Background.- Among the most common chronic pain conditions, yet poorly understood, are temporomandibular disorders (TMDs), with a prevalence estimate of 3-15% for Western populations. Although it is increasingly acknowledged that central nervous system mechanisms contribute to pain amplification and chronicity in TMDs, further research is needed to unravel neural correlates that might abet the dev

PurposeTo compare the diagnostic accuracy of the Heidelberg Retina Tomograph's (HRT) Moorfields regression analysis (MRA) and glaucoma probability score (GPS) with that of subjective grading of optic disc photographs performed by ophthalmologists with varying experience of glaucoma and by ophthalmology residents.MethodsDigitized disc photographs and HRT images from 97 glaucoma patients with visual

The investigation of periodic motions of constrained multibody systems requires the numerical solution of differential-algebraic boundary value problems. After briefly surveying the basics of periodic motion analysis the paper presents an extension of projected collocation methods [6] to a special class of boundary Value problems for multibody system equations with position and velocity constraint

BACKGROUND: In Crohn's disease high tissue expression and serum levels of chemokines and their receptors are known to correlate with disease activity. Because statins can reduce chemokine expression in patients with coronary diseases, we wanted to test whether this can be achieved in patients with Crohn's disease. METHODOLOGY/PRINCIPAL FINDINGS: We investigated plasma levels of chemokines (CCL2, C

Abstract in Italian Come gli altri dialetti della penisola salentina, il dialetto di Gallipoli è caratterizzato da un uso limitato dell’infinito. In alternativa alle costruzioni infinitive dell’italiano standard, il Gallipolino ricorre a costruzioni di forma finita rette da due complementatori: ka e ku. Tradizionalmente, il sistema di complementazione dei dialetti italiani meridionali è stato illuLike the other dialects spoken in the Salentine peninsula, the dialect from Gallipoli, Gallipolino, presents a limited use of infinitival clauses. Instead of several infinitival constructions as in standard Italian, we find some finite constructions introduced by two different complementizers: ka and ku. Traditionally, the phenomenon of the double complementation system in Southern Italian dialect

This article presents and analyses a new public Muslim voice that emerged in the political aftermath of the terrorist attacks in London in July 2005, in which the government reviewed its relations with Muslim communities. The Sufi Muslim Council (SMC) immediately attracted attention and criticism when it was launched in 2006, but it has not been studied in detail before. This article addresses the

The 39-item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient-reported rating scale in Parkinson's disease (PD). However, recent studies have questioned its validity and it is unclear what scores represent. This study explored the possibility of regrouping PDQ-39 items into scales representing the International Classification of Functioning, Disability, and Health (ICF) co

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