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Transgenerational sex determination: the embryonic environment experienced by a male lizard affects the sex ratio of his offspring

Conditions experienced during embryonic development can have lasting effects, even carrying across generations. Most evidence for transgenerational effects comes from studies of female mammals, with much less known about egg-laying organisms or paternally-mediated effects. Here we show that offspring sex can be affected by the incubation temperature its father experiences years earlier. We incubat

Integration and fusion of standard automated perimetry and optical coherence tomography data for improved automated glaucoma diagnostics

Abstract in Undetermined Background: The performance of glaucoma diagnostic systems could be conceivably improved by the integration of functional and structural test measurements that provide relevant and complementary information for reaching a diagnosis. The purpose of this study was to investigate the performance of data fusion methods and techniques for simple combination of Standard Automate

Prediction of Alzheimer’s disease in subjects with Mild Cognitive Impairment using biomarkers

Popular Abstract in Swedish Alzheimers sjukdom (eng. Alzheimer’s disease, AD) är den vanligaste orsaken till de- mens. Demens innebär en permanent sänkning av intellektuella förmågor som påverkar individen påtagligt i vardagen. Förekomsten av demenssjukdomar ökar betydligt efter 65 års ålder. AD är en långsamt progredierande sjukdom, som oftast börjar med försämrat närminne. Redan idag är AD en beBackground: Alzheimer’s disease (AD) is the most common cause of dementia. In order to have effect of future disease-modifying therapies for AD, the disease must be identified early, before the patients have developed dementia. Many patients with Mild Cognitive Impairment (MCI) have prodromal AD, but other causes for the syndrome are common. No diagnostic method can identify AD in patients with MC

Mechanism of (1)H-(14)N cross-relaxation in immobilized proteins.

A resonant enhancement of the water-(1)H relaxation rate at three distinct frequencies in the range 0.5-3MHz has been observed in a variety of aqueous biological systems. These so-called quadrupole (Q) peaks have been linked to a dipolar flip-flop polarization transfer from (1)H nuclei to rapidly relaxing amide (14)N nuclei in rotationally immobilized proteins. While the Q-peak frequencies conform

On the New Passive

The so-called New Passive in Icelandic takes the form 'it was elected us' (or, e.g., 'then was elected us', without an expletive), instead of the standard passive form 'we were elected'. It has neither A-movement to subject nor acc-to-nom conversion, which are otherwise diagnostic of the canonical passive in Icelandic and related languages. Some researchers have argued that "passive" is in fact a

On the relationship between economic rent and profit

The question of who appropriates the economic rents created by resources and capabilities has remained largely unresolved in strategic management. The aim of this paper is to highlight the problem established strategic management theory faces in explaining value appropriation, and to propose a framework that addresses how R&C affect bargaining power and value appropriation. While resource-base

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Abstract in Spanish Los rituales indígenas acompañaron a Evo Morales a través de sus primeros años como presidente de Bolivia. El oficio y las prácticas rituales del curandero y sabio aymara, el yatiri, están pasando por interesantes transformaciones, entrando a espacios políticos donde no solían estar presentes. ¿Pero cuál es realmente el papel que juegan el conocimiento terapéutico y la prácticaIndigenous rituals escorted Evo Morales throughout his first years as president of Bolivia. The art and the ritual practices of the yatiri, the Aymara healer and ritual specialist, are going through interesting transformations entering new political spaces of power. But which role does this therapeutic knowledge and ritual practice actually play in the present political process and how should this

On the strategies for incorporating nanosilica aqueous dispersion inthe synthesis of waterborne polyurethane/silica nanocomposites:Effects on morphology and properties

In this work the synthesis of waterborne polyurethane/nanosilica nanocomposites by using two differ-ent strategies is presented, starting from a vinyl terminated polyurethane prepolymer (PUP) based onisophorone diisocyanate and polypropylene glycol, and varying the nanosilica content. In one case, thePUP was dispersed in an aqueous solution containing glycerol-functionalized colloidal nanosilica p

Health in Hand: Putting mHealth Design in Context

Wireless technologies, cloud computing and connectivity have enabled mobile services that extend the coverage of health services, resulting in a branch of eHealth now commonly referred to as mHealth. However, at least in Sweden, where the healthcare sector is heavily institutionalized and regulated, mHealth has so far mainly evolved in the form of applications for support of healthy life-style and

Evaluation of a setup for pNRA at LIBAF for applications in geosciences

A new setup for photon tagged nuclear reaction analysis pNRA is being developed at Lund's ion beam analysis facility LIBAF. Particle induced gamma ray emission PIGE and nuclear reaction analysis NRA are two methods that have been extensively used for light isotope measurement in ion beam analysis IBA. There is an abundance of nuclear reactions between light elements and MeV protons, deuterons and

A multi-criteria evaluation framework for tradable white certificate schemes

Recent years have witnessed regained political momentum on energy efficiency and interest in establishing markets is growing. As a result, Tradable White Certificate (TWC) schemes of differing design have been implemented in Great Britain, Italy and France. Much attention is being paid to justifying and evaluating such schemes. In this paper, we develop and apply a multi-criteria framework for eva

Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.

Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasquinimod is the inflammatory protein S100A9 which has been shown to affect the accumulation and function of suppressive myeloid cell subsets in tumors. Given the m

The evaluation of climate policy: theory and emerging practice in Europe

Climate policy is a relatively young and dynamic area of public policy making. However, its development has attracted far more attention than the results it delivers in practice, which of course are the concern of policy evaluators. This article attempts to provide the first systematic cataloging of the emerging patterns of policy evaluation undertaken in different parts of the European Union. The

Imaging of gynecological disease (6): clinical and ultrasound characteristics of ovarian dysgerminoma

Objectives To describe the clinical history and ultrasound findings in patients with ovarian dysgerminoma. Methods This was a retrospective study of patients with a histological diagnosis of ovarian dysgerminoma who had undergone preoperative ultrasound examination. The patients were identified from the databases of 11 ultrasound centers. The tumors were described by the principal investigator at