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TVnet : Automated Time-Resolved Tracking of the Tricuspid Valve Plane in MRI Long-Axis Cine Images with a Dual-Stage Deep Learning Pipeline

Tracking the tricuspid valve (TV) in magnetic resonance imaging (MRI) long-axis cine images has the potential to aid in the evaluation of right ventricular dysfunction, which is common in congenital heart disease and pulmonary hypertension. However, this annotation task remains difficult and time-demanding as the TV moves rapidly and is barely distinguishable from the myocardium. This study presen

Tool Wear and Vibrations Generated When Turning High-chromium White Cast Iron with pCBN Tools

Dynamic behavior and stability of system 'tool-workpiece' when machining HCCI with pCBN tools are determined by the processes which occur in cutting zone. The cutting process is characterized by formation of tool protection layer (TPL) on the chip contact area but its stability depends on the workpiece material composition, tool material and cutting conditions. The higher content of Si in the HCCI

Reduced ability to produce reflex-evoked neurogenic inflammation, a sign of decreased defense against COVID-19 infection?

Background: A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?. Materials and methods: Histamine SPT

Numerical Determination of Process Values Influencing the Surface Integrity in Grinding

Internal traverse grinding with electroplated cBN wheels using high-speed process conditions combines high material removal rates and a high surface quality of the workpiece in one single grinding stroke. In order to capture the macroscopic and mesoscopic thermo-mechanical loads onto the workpiece during internal traverse grinding, numerical simulations are conducted at the two scales. This result

Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside

Galectin-8 has gained attention as a potential new pharmacological target for the treatment of various diseases, including cancer, inflammation, and disorders associated with bone mass reduction. To that end, new molecular probes are needed in order to better understand its role and its functions. Herein we aimed to improve the affinity and target selectivity of a recently published galectin-8 lig

The Adoption of Additive Manufacturing Technology in Sweden

This paper analyzes the adoption of Additive Manufacturing (AM) technologies in Sweden. The dataset consists of a recent and representative sample of Swedish AM users (companies, universities, and research institutes). The authors investigate two questions. Firstly, what are the current applications of AM in Sweden (e.g. Rapid Prototyping (RP), production)? Secondly, what are the factors that can

Comparison of posterior hyaloid assessment using preoperative optical coherence tomography and intraoperative triamcinolone acetonide staining during vitrectomy

Purpose: To compare the specificity of diagnosing posterior vitreous detachment (PVD) using preoperative optical coherence tomography (OCT) versus intraoperative triamcinolone acetonide (TA) staining in patients undergoing vitrectomy. Patients and Methods: This retrospective cohort study included patients undergoing pars plana vitrectomy for diverse retinal pathologies. Intraoperatively, surgeons

Transductive Image Segmentation : Self-training and Effect of Uncertainty Estimation

Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications, however, our primary interest is not generalization but to obtain optimal predictions on a specific unlabeled database that is fully available during model development

Space and the emotional topography of populism in Turkey : The case of Hagia Sophia

Over the past decade, as ruling Justice and Development Party (AKP) initiated Turkey’s authoritarian populist turn, it sought to derive legitimacy through extra-institutional avenues, notably the emotional appeal to the repressed “people”, advancing the party’s socio-political vision, countering the arguments of its political opponents and reaching out to, and inspiring its constituency. Turkey’s

Instantaneous wave-free ratio compared with fractional flow reserve in PCI : A cost-minimization analysis

Background: Coronary physiology is a routine diagnostic tool when assessing whether coronary revascularization is indicated. The iFR-SWEDEHEART trial demonstrated similar clinical outcomes when using instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) to guide revascularization. The objective of this analysis was to assess a cost-minimization analysis of iFR-guided compared with F

Contextual and evolutionary perspectives on entrepreneurial ecosystems. Insights from Chris Freeman’s thinking

In recent years a concept gaining much traction amongst both economic and policy communities is that of Entrepreneurial Ecosystems (EE). We are interested in this concept because it has clear roots in innovation system thinking and can be argued to represent a contemporary iteration of ideas around systemic understandings and policy approaches to economic development, innovation, and entrepreneurs

Layout-Agnostic Order-Batching Optimization

Order-batching is an important methodology in warehouse material handling. This paper addresses three identified shortcomings in the current literature on order-batching optimization. The first concerns the overly large dependence on conventional warehouse layouts. The second is a lack of proposed optimization methods capable of producing approximate solutions in minimal computational time. The th

A new protocol for exercise testing in COPD; improved prediction algorithm for WMAX and validation of the endurance test in a placebo-controlled double bronchodilator study

Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (COPD) with an individualized cardiopulmonary exercise test (ICPET) and subsequent customized endurance test (CET), which generate less interindividual spread in endurance time compared with the standard endurance test. Main objectives of this study were to improve the prediction algorithm f

Clinical interpretation and cutoff scores for manual ability measured by the ABILHAND questionnaire in people with stroke

Background: The ABILHAND questionnaire is recommended to assess perceived manual ability after stroke; however, more knowledge on interpretability is needed to improve the clinical applicability. Objectives: To determine clinically meaningful cutoff scores for different levels of perceived manual ability, assessed by ABILHAND, corresponding to established observed and perceived upper extremity ass

Emerging Roles of DLK1 in the Stem Cell Niche and Cancer Stemness

DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane protein Delta-like homologue 1 (DLK1), a non-canonical NOTCH ligand with well-described roles during development, and tumor-supportive functions in several aggressive cancer forms. Here, we review the many functions of DLK1 as a regulator of stem cell pools and tissue differentiation in tissues such as brain, mu

Sense of coherence and changes over six years among older adults aging with long-term spinal cord injury

Study design: Cross-sectional and longitudinal. Objectives: To (i) describe sense of coherence (SOC) and changes over six years in older adults aging with long-term spinal cord injury (SCI) and (ii) investigate how changes in SOC are associated with injury characteristics and changes in sociodemographics and secondary health conditions (SHCs; bowel-related and bladder-related problems, pain and sp

Impact of corporate governance on financial performance : The case of listed warehouse transportation firms in emerging economy

Corporate governance structures are expected to help a firm have better financial performance through giving proper decision-making (Shivani, Jain, & Yadav, 2017). In recent years, along with the completing process of the business environment, the corporate governance framework in Vietnam has also been gradually built and implemented. However, corporate governance in Vietnam still has some lim