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A LASTING ANTI-TUMOR RESPONSE Cancer and its treatment have been a hot topic in research for quite a while. Despite, it being well researched, researchers still have not come up with one magic bullet. Will they ever though, is the question? Or should we be satisfied with several working treatments for individual cancers and patients? If we were only this far, since there are still some cancer typ
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by an accelerated decline in lung function due to narrowing and fibrosis of small airways and irreversible alveolar tissue destruction termed as emphysema. To date, no effective treatments exist which can reverse the damaged state of the affected lungs. Stem cell therapy represents a promising approach for tar
The design field is at a determining moment, with socially and environmentally imminent threats in the coming decades. To tackle such complex problems requires extensive and adaptive responses. Design at the intersection of anthropology, sustainability and innovation is the most pressing discussion of our time (Erickson, 2003). A starting point for designers could be to start digging were we st
En obefogad rädsla? Lite tyder på att beteendeeffekter hos den Stora dammsnäckan kan förklaras av det antidepressiva preparatet fluoxetin Vad händer egentligen med ett läkemedel när det har transporterats ut från kroppen? Många ämnen transporteras genom reningsverk till närliggande vattendrag utan att fullständigt nedbrytas och kan då förändra beteendet hos det akvatiska djurliv som kommer i kontThe use of selective serotonin reuptake inhibitors (SSRI), a group of antidepressants, increases globally resulting in higher concentrations also in wastewater recipients. These concentrations may cause altered behaviour of aquatic organisms and have effects on whole ecosystem level. Therefore, the objective of this study was to assess if seven days of exposure to concentrations ranging between 0,
Three-dimensional (3D) city models are increasingly utilized among stakeholders of different sectors, particularly those dealing with building information. 3D city models are a three-dimensional digital representation of urban structures, most prominently buildings. They offer diverse applications and have gained wide acceptance as a support tool in planning practices. The push to achieve greater
Denna uppsats undersöker rättsläget för bostadshyresgästernas besittningsskydd och när den aktualiseras. Bostadshyresgäster har ett förstärkt skydd gentemot hyresvärden för att inte frånskiljas från sin bostad utan saklig grund. Detta skydd förlänger bostadshyresgästernas hyresavtal. Dock finns det vissa undantag som sätter besittningsskyddsreglerna ur spel. Vidare kan parterna sinsemellan avtala This essay examines the legal situation for residential tenants’ possession protection and when this protection can be used. Residential tenants have an enhanced protection against the landlord to not be separated from their homes without objective grounds. This protection works to extend the tenants’ rental agreements. However, there are some exceptions that puts the possession protection rules o
Sweden has expressed a commitment to children’s rights in the last few decades, signing the UN Convention on the Rights of the Child (UNCRC) in 1990 and eventually incorporating it as Swedish law in 2020. With the Covid-19 pandemic coinciding with the convention as law and drastically changing the lives of many, including those of children and youth, what role do children’s rights play during a gl
I takt med att världen blir mer datadriven flyttas allt fler stora beräkningar till molnet. Då tillkommer ofta problem med filhantering. Detta examensarbete bidrar med ett nytt sätt att dela filer med molnet, där molntjänsten får tillgång till filer som lagras på användarens dator.Data science development largely revolves around working in notebooks, and these usually run in a cluster environment. These cloud notebooks do however come with limitations. Support for tools like version control, testing, refactoring and linting is limited, which negatively impacts developer experience and software quality. We propose a networked file system for sharing local files and director
På Gotland tonar knotiga, skulpturala tallar upp sig och den vita kalkstenen ger ön ett alldeles eget ljus som har gjort intryck på flertalet besökare. Carolina Benedicks Bruce och hennes man William valde ön för konsten och det var genom den hon väckte mitt intresse. Det nationella kulturarv de skapade och deras konstnärshem Brucebo blev utgångspunkten jag ville bygga vidare på i mitt examensarbeAt Gotland, gnarled sculptural pine trees rise and the white limestone creates a unique light that has made an impression on many visitors. Carolina Benedicks Bruce and her husband William chose to settle on the island to benefit their art which caught my interest from an early age. They created a national cultural heritage and their home Brucebo became the starting point from which I decided to b
Kroniska hjärtsviktspatienters egenvård och reglering av diuretika dosering – Koncept och arkitektur av ett beslutsstödsystem Hjärtsviktspatienter har behov av nya lösningar för att underlätta deras egenvård och att bibehålla sin hälsa. I arbetet har därmed ett beslutsstöd utvecklats för att stödja patienten att bedöma sitt tillstånd och reglera ett av sina läkemedel. Brödtexten Hjärtsvikt är eFluid overload is the build up of excessive fluid in the body and is a common condition amongst chronic heart failure patients. Fluid overload is treated with diuretics but the level of excessive fluid can vary. To match the fluctuations a flexible diuretics regime may be prescribed where patients are instructed to temporarily increase the dosage upon onset or worsening of fluid overload. In this
Den så kallade standardmodellen har länge betraktats som en av den moderna vetenskapens triumfer, tack vare dess oerhört exakta förutsägelser, som gång på gång har verifierats av experiment. Men från dess begynnelse har den alltid varit inkomplett: inte nog med att gravitationen, den kraft som vi människor är mest bekanta med, inte ens inkluderas i den så har olika, tidigare okända fenomen blivit In this project a two Higgs doublet model with a complex singlet and an extra family symmetry providing a mechanism for suppression of flavor changing neutral currents is explored. The goal is to investigate the phenomenological consistency of the model using a custom software framework. To this end, the scalar and Yukawa sectors of this extension of the Standard Model are explored in detail. The
Klimatförändringar och överkonsumtion av fossila naturresurser har skapat ett behov av en energiproduktion som baseras på förnybara energikällor, däribland biomassa innehållandes lignocellulosa. Restavfall från jordbruket, som vetehalm, är material innehållandes lignocellulosa som kan bidra till energitillförseln om de används till biogasproduktion. Ett problem med biogasproduktion från sådana matClimate change and depletion of fossil resources have generated a need for energy production based on renewable resources such as lignocellulosic biomass. Agricultural residues, like wheat straw, is lignocellulosic biomass that could contribute to the energy supply if it was used for biogas production. One issue with biogas production from lignocellulosic materials is, however, the high content of
The Brundtland report envisioned three sustainable dimensions for development: economic growth, ecological balance, and social inclusion with the aim to incorporate these dimensions into local, national, and global plans for sustainable development. In recent years, discussions about our society’s competitiveness and whether the three dimensions of sustainable development include all aspects of ou
When technology meets cell biology Lysosomes are small bags present in our cells that are filled with destructive molecules, normally needed for removing cell garbage. In some cases, these bags rupture and their contents leak into the interior of the cell leading to cell death. This can contribute to many diseases, such as Alzheimer’s disease. However, rupturing lysosomes intentionally, can also
The immune system is the main defense barrier against infections but exerts selection pressures on other life history traits. Recent studies have given importance to understanding the role of the immune system in birds, and it has been hypothesized that during migration, birds either increase their immune function, as they might encounter novel pathogens, or decrease it to account for the cost of
Analysis of priming and licensing signals detected by pattern recognition receptors in murine macrophages Vårt immunsystem är uppdelat i två delar, det medfödda och det adaptiva. Det medfödda immunsystemet består av fysiska (hud och slem) och kemiska barriärer (lågt pH i magen och amylaser i saliv), samt cellulära komponenter. I den cellulära komponenten av det medfödda immunsystemet finns en väl
