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Improving missing value imputation of microarray data by using spot quality weights

Background Microarray technology has become popular for gene expression profiling, and many analysis tools have been developed for data interpretation. Most of these tools require complete data, but measurement values are often missing A way to overcome the problem of incomplete data is to impute the missing data before analysis. Many imputation methods have been suggested, some naïve and other mo

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Medieval round churches are often seen as riddles in need of special explanation. Deviant architecture has been explained by three major theories – fortification, multi-functionality and symbolic copying. However, I claim that the round churches were normal except for their elite context and extraordinary plan. I then argue, that the elite consciously choose a “conspicuous architecture”, to use a

Öppen dörr till klassrummet

Under den senaste tioårsperioden har ofta förhållandena i grundskolan varit på tapeten. Ett tag var alla skoldebattörer helt enkelt tvungna att tala om "grundskolans kris". I denna debatts kölvatten kom en rad välmenande, bakåtsträvande, framåtsyftande reformförslag. Tvång, mindre klasser, normer, nivågruppering, basfärdigheter, ordning och reda och allt vad det nu var. Stundtals kom också autenti

Theoretical analysis of mean effective gain of mobile terminal antennas in Ricean channels

The mean effective gain (MEG) for Rice distributed signals impinging at the terminal receiver antenna is presented. Numerical results are presented for three different angular probability distributions of impinging waves. Finally, it is shown that contrary to the Rayleigh channels in Ricean channels there is no inclination angle at which the MEG of the half-wave dipole antenna remains constant reg

Fire safety Design Based on Risk Assessment

The present paper concerns a performance-based fire safety analysis and design of a high-rise building. The resulting fire safety recommendations are compared with those specified by acceptable solutions in terms of the earlier prescriptive building code. The respective risk to life resulting from the analysis is compared and discussed. The benefit and need of using a risk based verification metho

Causes of Surgical Delay and Demographic Characteristics in Patients with Hip Fracture

Background: Several studies analyze how surgical delay affects patients with hip fracture. The aim of this study was to identify the causes of surgical delay and demographic characteristics in patients with hip fracture who had delays longer than 24 hours from admission to hospital. Methods: Quantitative retrospective register study of 484 patients was consecutively included during the period Nove

Psychometric performance of a generic walking scale (Walk-12G) in multiple sclerosis and Parkinson's disease.

Walking difficulties are common in neurological and other disorders, as well as among the elderly. There is a need for reliable and valid instruments for measuring walking difficulties in everyday life since existing gait tests are clinician rated and focus on situation specific capacity. The Walk-12G was adapted from the 12-item multiple sclerosis walking scale as a generic patient-reported ratin

Learning and Planning of Situated Resource Bounded Agents

This paper presents an investigation of rational agents that have limited computational resources and that can interact with their environments. We analyse how such agents can combine deductive reasoning using domain knowledge and inductive learning from past experiences, while remaining time-aware in a manner appropriate for beings situated in a dynamic universe. In particular, we consider how th

Cyclosporine, tacrolimus and sirolimus retain their distinct toxicity profiles despite low doses in the Symphony study.

BACKGROUND: Reducing side effects of immunosuppressive regimens has become a priority in transplantation medicine because of the large number of patients and grafts that succumb to infection in the short term and cardiovascular disease in the long term. The Symphony study was a 12-month prospective, randomized, open-label, multi-centre, four parallel arm study that aimed to evaluate the safety and