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We analyzed a cohort of 599 cases of urothelial carcinoma for EGFR, ERBB2, and ERBB3 gene expression and genomic alterations. The cohort consisted of a reference set (n = 292) comprising all stages and grades and one set (n = 307) of advanced tumors. All cases were previously classified into urothelial carcinoma molecular subtypes. Genomic amplifications were established by array-CGH or in-situ hy

Infant botulism means that Clostridium botulinum colonize and produce toxin in the infant gut, usually during the first year of life. Illness severity varies widely and the incidence may be under-estimated. Infant botulism should be considered in cases of acute muscle weakness or floppiness in infants, especially when accompanied by constipation or feeding difficulties. Respiratory failure and nee

Pump-based Parkinson (PD) therapies, including subcutaneous apomorphine infusion (CSA) and levodopa-carbidopa intestinal gel (LCIG), presently constitute the most effective pharmacological treatments available for advanced PD. These therapies are based on a more constant delivery of the dopaminergic drug resulting in a more continuous dopaminergic stimulation and a more stable treatment effect. Th

Background: The Montreal Cognitive Assessment (MoCA) has a high sensitivity for detecting cognitive dysfunction. Swedish normative data does not exist and international norms are often derived from populations where cognitive impairment has not been screened for and not been thoroughly assessed to exclude subjects with dementia or mild cognitive impairment. Objective: To establish norms for MoCA a

Purpose To describe and comment on the treatment of the slipped capital femoral epiphysis (SCFE) with pinning and to present the pros and cons of prophylactic pinning of the contralateral hip. Summary Pinning the SCFE aims to fix the epiphysis and prevent further slipping. Some devices allow for further growth and remodeling of the femoral neck post-operatively. This results in maintained femoral

The Swedish Poisons Information Centre, a nationwide 24/7 service to healthcare providers and the public, answers many questions about serious cases of acute poisoning. In some of these, prompt and proper treatment recommendations can be crucial for the clinical outcome. In cases where self-reported information is missing or considered unreliable, more emphasis is placed on the clinical symptoms a

Objective: To describe and evaluate a reproducible, anatomically based surgical algorithm, including reinjection of tracer to enhance technical success rate, for detection of pelvic sentinel lymph nodes (SLNs) in endometrial cancer (EC). Methods: A prospective study of 102 consecutive women with high risk EC scheduled for robotic surgery was conducted. Following cervical injection of a fluorescent

Transforming growth factor-β (TGFβ) is a member of a large family of polypeptide growth factors. TGFβ signals mainly through the intracellular proteins Smad2 and Smad3, which are highly similar in amino acid sequence identity. A number of studies have shown that these proteins, dependent on context, have distinct roles in the TGFβ signaling pathway. TGFβ is one of the most potent inhibitors of hem

Background: During rubber vulcanization, new compounds can be formed. Objectives: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). Methods: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the Europea

Objectives: Guidelines recommend a 0-hour/1-hour high-sensitivity cardiac troponin T (hs-cTnT) diagnostic strategy in acute chest pain patients. There are, however, little data on the performance of this strategy when combined with clinical risk stratification. We aimed to evaluate the diagnostic accuracy of an accelerated diagnostic protocol (ADP) using the 0-hour/1-hour hs-cTnT strategy together

This thesis muses the question; how do we understand firm growth in immigrant owned firms? Two literature streams are proposed to be relevant. Firstly, theimmigrant entrepreneurship field, which is developing and becoming increasinglysophisticated. Though despite appeals from within the field, that we need a widerspan of concepts to explain the changing heterogeneity and fabric of immigrantentrepr

In this paper, scattering of electromagnetic waves by discrete, randomly distributed objects inside a (finite thickness or semi-infinite) slab is addressed.In general, the non-intersecting scattering objects can be of arbitrary form, material and shape with a number density of $n_0$ (number of scatterers per volume).The main aim of this paper is to calculate the coherent reflection and transmissio

In this eye-tracking and drawing study, we investigate the perceptual grounding of different types of spatial dimensions such as DENSE–SPARSE and TOP–BOTTOM, focusing both on the participants’ experiences of the opposite regions, e.g., O1: DENSE; O2: SPARSE, and the region that is experienced as intermediate, e.g., INT: NEITHER DENSE NOR SPARSE. Six spatial dimensions expected to have three differ

Ideation means to generate ideas, and when involving non-designers in these activities they need to be informed about the scope of the possibilities without limiting their imagination. This is a general challenge, which becomes particularly important when it comes to advanced technology ideation together with participants that may not have in-depth knowledge of technological designs and solutions.

Entreprenörskap och egenföretagande framställs idag som betydelsefulla faktorer avseende både tillväxt, sysselsättnings- och integrationsproblem. I en ny kunskapsöversikt presenteras och diskuteras kunskap om invandring och företagande ur ett internationellt och svenskt perspektiv. Översikten redogör för om det finns något särskilt som karaktäriserar utlandsföddas företagande exempelvis vad gäller

In recent years entrepreneurship has become one of the most popular fields of research in management studies. As the subject has broadened, increasing attention has been paid to the behavioural aspects of different practices to identify and pursue entrepreneurial opportunities. This timely book analyses three key strands of contemporary research into entrepreneurial behaviour: intention, education

Soft tissue tumors (STT) constitute a heterogeneous group of tumors that arise in tissues of mesenchymal origin. They are currently classified according to morphology and resemblance to normal tissue into over 100 subtypes. Differentiation between the different subtypes can sometimes be difficult, and along with the fact that little is known about the mechanisms of STT development, this makes adeq