Background: Current evidence on chronic disease prevention suggests that interventions targeted at high-risk individuals represents the best way forward. We implemented a step-wise approach in the Danish primary care sector, designed for the systematic and targeted prevention of chronic disease. The intervention centered on a personal digital health profile for all participants, followed by target

Background: In patients with cardiac resynchronization therapy (CRT), atrial fibrillation (AF) is associated with an unfavorable outcome and may cause loss of biventricular pacing (BivP). An effective delivery of BivP of more than 98% of all ventricular beats has been shown to be a major determinant of CRT-success. Methods: At a Swedish tertiary referral center, data was retrospectively obtained f

In this study we use a sample of about 9 million SkyMapper stars with metallicities to investigate the properties of the two stellar populations seen in the high-velocity (V T > 200 km s-1) Gaia DR2 Hertzsprung-Russell diagram. Based on 10,000 red giant branch (RGB) stars (out of 75,000 with high velocity), we find that the two sequences have different metallicity distribution functions; one peaks

Rapporten består av en policy-analys gällande internationella, nationella, regionala och lokala (Malmö och Göteborg) policys som berör bilfria urbana distrikt eller implementering av sådana områden. Detta arbete är en del av projektet ”Bilfria urbana distrikt”, som är ett gemensamt forskningsprojekt mellan Lunds universitet, Sveriges landsbruksuniversitet (SLU) och Chalmers i Göteborg. Dokumenten

Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while outperforming established tags like the HA-, FLAG®- or myc-tag. The ALFA-tag forms a small and stable α-helix that is func

Aim To present a systematic literature review (SLR) on efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD), aiming to provide a basis for updating the EULAR evidence-based recommendations. Methods An SLR was performed according to the standard operating procedures for EULAR-endorsed recommendations. Outcome was determined by

Context. In the era of large high-resolution spectroscopic surveys such as Gaia-ESO and APOGEE, high-quality spectra can contribute to our understanding of the Galactic chemical evolution by providing abundances of elements that belong to the different nucleosynthesis channels, and also by providing constraints to one of the most elusive astrophysical quantities: stellar age. Aims. Some abundance

The LHC Higgs data are showing a gradual inclination towards the standard model (SM) result, and realization of a SM-like limit becomes essential for beyond the SM scenarios to survive. Considering the accuracy that can be achieved in future colliders, models beyond the standard model that acquire the alignment limit with a SM-like Higgs boson can surpass others in the long run. Using a convenient

Renovating the European building stock has for almost two decades been a matter of importance to the European Union. Reduction of energy use for existing buildings can be achieved through applying energy efficiency renovation measures. Besides this, there is quite a large renovation need in Sweden due to building materials and services reaching (or having passed) the end of their service life.IncoRenovating the European building stock has for almost two decades been a matter of importance to the European Union. Reduction of energy use for existing buildings can be achieved through applying energy efficiency renovation measures. Besides this, there is quite a large renovation need in Sweden due to building materials and services reaching (or having passed) the end of their service life.Inco

Heritage buildings are usually culturally protected as well as naturally ventilated. As such, it is difficult to control the airflow, which depends on the temperature outdoors as well as the wind. This causes issues with the thermal comfort and the indoor air quality. In this study, status determinations were conducted for 12 heritage buildings with offices, across Sweden. Field measurements on te

1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators, for example, the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) relea

Synthesis of substituted 4-benzyloxypyridinium salts by the addition of Grignard reagents to pyridine N-oxides provides an efficient route for obtaining substituted 4-pyridones or 4-aminopyridinium salts.

Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.

(Figure presented) A conceptually new one-pot strategy for the synthesis of protected substituted piperazines via the addition of Grignard reagents to pyrazine N-oxides is presented. This strategy is high yielding (33-91% over three steps), step-efficient, and fast. The synthesized N,N-diprotected piperazines are convenient to handle and allow for orthogonal deprotection at either nitrogen for sel

We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3) are acti

Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chro

(formula presented) Temporary tethering using aluminum or zinc in Diels-Alder reactions made possible the use of otherwise "noncompatible" combinations of dienes and dienophiles, resulting in the one-step formation of substituted cyclohexene 1,2-bis-methanols. Excellent regioselectivity and also significant stereoselectivity were obtained.