The association between areas of secondary hyperalgesia and volumes of the caudate nuclei and other pain relevant brain structures—A 3-tesla MRI study of healthy men
Introduction Central sensitization plays a pivotal role in maintenance of pain and is believed to be intricately involved in several chronic pain conditions. One clinical manifestation of central sensitization is secondary hyperalgesia. The degree of secondary hyperalgesia presumably reflects individual levels of central sensitization. The objective of this study was to investigate the association