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A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy : Design, Dosimetry and Biological Pilot Study

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. W

Optimized Workflow Framework in Construction Projects to Control the Environmental Properties of Soil

To optimize the workflow of civil engineering construction in a harbour, this paper developed a framework of the contaminant leaching assessment carried out on the stabilized/solidified dredged soil material. The specimens included the sampled sediments collected from the in situ fieldwork in Arendal and Kongshavn. The background levels of the concentration of pollutants were evaluated to assess t

Fire carbon emissions over Equatorial Asia reduced by shortened dry seasons

Fire carbon emissions over Equatorial Asia (EQAS) play a critical role in the global carbon cycle. Most regional fire emissions (89.0%) occur in the dry season, but how changes in the dry-season length affect the fire emissions remains poorly understood. Here we show that, the length of the EQAS dry season has decreased significantly during 1979–2021, and the delayed dry season onset (5.4 ± 1.6 (±

Flow structure and dynamics behind cylinder arrays at Reynolds number ∼100

The flow behind nine different arrays of cylinders is experimentally investigated via Particle Image Velocimetry (PIV) at a Reynolds number of Re ∼ 100 based on the diameter of the cylinders. Each array consists of a column of four cylinders in front and three in the rear. The horizontal distance between the two columns and the vertical distance between the cylinders within each column are varied

Coronary microvascular dysfunction in Takotsubo syndrome and associations with left ventricular function

Aims: Coronary microvascular dysfunction (CMD) has been proposed as an important pathophysiological mechanism in Takotsubo syndrome (TTS). Our aims were (i) to evaluate and compare levels of CMD in patients with TTS and patients with ischaemia and no obstructive coronary arteries (INOCA) and (ii) to investigate associations between CMD and clinical parameters, left ventricular function, and corona

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The NSP15 endoribonuclease enzyme, known as NendoU, is highly conserved and plays a critical role in the ability of the virus to evade the immune system. NendoU is a promising target for the development of new antiviral drugs. However, the complexity of the enzyme's structure

Nordic 2023 guidelines for the diagnosis and treatment of lung neuroendocrine neoplasms

Lung neuroendocrine neoplasms (NEN) are a heterogeneous population of neoplasms with different pathology, clinical behavior, and prognosis compared to the more common lung cancers. The diagnostic work-up and treatment of patients with lung- NEN has undergone major recent advances and new methods are currently being introduced into the clinic. These Nordic guidelines summarize and update the Nordic

Evaluate Transformer model and Self-Attention mechanism in the Yangtze River basin runoff prediction

Study region: In the Yangtze River basin of China. Study focus: We applied a recently popular deep learning (DL) algorithm, Transformer (TSF), and two commonly used DL methods, Long-Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU), to evaluate the performance of TSF in predicting runoff in the Yangtze River basin. We also add the main structure of TSF, Self-Attention (SA), to the LSTM and G

Toward the end-to-end optimization of particle physics instruments with differentiable programming

The full optimization of the design and operation of instruments whose functioning relies on the interaction of radiation with matter is a super-human task, due to the large dimensionality of the space of possible choices for geometry, detection technology, materials, data-acquisition, and information-extraction techniques, and the interdependence of the related parameters. On the other hand, mass

Cache-Timing Attack Against HQC

In this paper, we present the first chosen-ciphertext (CC) cache-timing attacks on the reference implementation of HQC. We build a cache-timing based distinguisher for implementing a plaintext-checking (PC) oracle. The PC oracle uses side-channel information to check if a given ciphertext decrypts to a given message. This is done by identifying a vulnerability during the generating process of two

Toroidal dipolar supersolid with a rotating weak link

Ring-shaped superfluids with weak links provide a perfect environment for studying persistent currents and dynamic stirring protocols. Here, we investigate the effects of a weak-link system on dipolar supersolids. By calculating the ground-state energy at fixed angular momenta, we find that metastable persistent currents may exist in the supersolid phase near the superfluid transition point. When

xtnumfac : A battery of estimators for the number of common factors in time series and panel-data models

In this article, we introduce a new community-contributed command, xtnumfac, for estimating the number of common factors in time-series and panel datasets using the methods of Bai and Ng (2002, Econometrica 70: 191–221), Ahn and Horenstein (2013, Econometrica 81: 1203–1227), Onatski (2010, Review of Economics and Statistics 92: 1004–1016), and Gagliardini, Ossola, and Scaillet (2019, Journal of Ec

Amyloids and protein aggregation

A general discovery in protein science in the past few decades has been the finding that a number of unrelated proteins and peptides all have a marked propensity to form amyloid fibrils in vivo and in vitro. These structures have become known as the pathological hallmark of some of the most prevalent neurodegenerative diseases. More recently, the process of amyloid formation has been demystified t

The Complex Exhumation History of Jezero Crater Floor Unit and Its Implication for Mars Sample Return

During the first year of NASA's Mars 2020 mission, Perseverance rover has investigated the dark crater floor unit of Jezero crater and four samples of this unit have been collected. The focus of this paper is to assess the potential of these samples to calibrate the crater-based Martian chronology. We first review the previous estimation of crater-based model age of this unit. Then, we investigate

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SAR images are important data for observing the earth in all weather conditions. But the speckle noise contaminated the SAR images, obstructs their application. Speckle noise is primarily due to the phase fluctuations of the electromagnetic return signals. In this paper, we investigate the effect of speckles on the change detection result. Two cost functions are used in our change detection algori

Direct Determination of the Rate of Intersystem Crossing in a Near-IR Luminescent Cr(III) Triazolyl Complex

A detailed understanding of the dynamics of photoinduced processes occurring in the electronic excited state is essential in informing the rational design of photoactive transition-metal complexes. Here, the rate of intersystem crossing in a Cr(III)-centered spin-flip emitter is directly determined through the use of ultrafast broadband fluorescence upconversion spectroscopy (FLUPS). In this contr

Melanin-based plumage coloration is associated with exposure in tawny owls under novel conditions

Abstract: Intraspecific color variation is often associated with camouflage or protection, but melanin-based color variation is also linked to behavioral and physiological aspects including boldness. In the melanin-based plumage color polymorphic tawny owl (Strix aluco), the grey morph is known to be more cryptic than the brown morph. Using 19 captive tawny owls (11 grey and 8 brown), we tested if