Context: Grading is the mainstay for treatment decisions for patients with non–muscle-invasive bladder cancer (NMIBC). Objective: To determine the requirements for an optimal grading system for NMIBC via expert opinion. Evidence acquisition: A multidisciplinary working group established by the International Society of Urological Pathology reviewed available clinical, histopathological, and molecul

Background: Congenital diaphragmatic hernia (CDH) reportedly has neurologic consequences in childhood however little is known about the impact in isolated CDH. Aims: Herein we aimed to describe the risk of neurodevelopmental complications in children born with isolated CDH. Materials & Methods: We systematically reviewed literature for reports on the neurological outcome of infants born with i

Museum collections around the world contain billions of specimens, including rare and extinct species. If their genetic information could be retrieved at a large scale, this would dramatically increase our knowledge of genetic and taxonomic diversity information, and support evolutionary, ecological and systematic studies. We here present a target enrichment kit for 2953 loci in 1753 orthologous n

The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. The topics covered include the post-cardiac arrest syndrome, diagnosis of cause of cardiac a

We study the long-term impact of a policy-driven change in childhood nutrition. For this purpose, we evaluate a program that rolled out nutritious school lunches free of charge to all pupils in Swedish primary schools between 1959 and 1969. We estimate the impact of the program on children's economic, educational, and health outcomes throughout life. Our results show that the school lunch program

Research has demonstrated how ignorance is made, manipulated and called upon; how it is the result of strategies, activities and structures. This article extends the literature on ignorance by exploring actors’ own explanations of their self-inflicted ignorance following acts of ignoring. By means of a case analysis, we explore how actors explain and justify ignoring data they themselves produced.

Objective: A large number of atrial fibrillation (AF) detectors have been published in recent years, signifying that the comparison of detector performance plays a central role, though not always consistent. The aim of this study is to shed needed light on aspects crucial to the evaluation of detection performance. Methods: Three types of AF detector, using either information on rhythm, rhythm and

Frans Libertson och Jenny Palm skriver om vikten av att nyansera debatten om Sveriges elförsörjning med fler perspektiv på energisystemets utformning. Under det senaste 10 åren har frågan främst diskuterats utifrån ett centraliserat perspektiv, dvs att elproduktionen ska ske i storskaliga anläggningar och att besluten som styr produktionen tas på nationell nivå. Detta snäva fokus riskerar att förb

Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020. During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital admissions, 207 intensive care admissions and 126 deaths. We aimed to identify the source and number of introductions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into Scotland using a combined phylogenetic and

DEBATT. Frågan om det finns en betalningsvilja för fossilfritt stål är vilseledande. I en ekonomi som når klimatmålen måste allt stål vara fossilfritt oavsett pris. Det skriver några forskare i en replik till ”Är det gröna stålet verkligen grönt” av Henrekson, Sandström och Terjesen 1/4.

Todays dispruptive technologies will change the layout of our cities and change urban life. Discussing what future cities need to thrive, how aesthitic value arises from embodied interaction and the need for walkable landscapes, I suggest that enviroments that afford placing the second person first will make us more kind.

The enzymatic production of prebiotic xylooligosaccharides (XOS) has become an attractive way to valorise lignocellulosic biomass. However, despite numerous xylanases reported for potential use in the production of XOS, most of the family GH10 also produce xylose. This monosaccharide can negatively affect the selectivity to stimulate the growth of intestinal microorganisms beneficial to human heal

Modification of alkyl glycosides, to alter their properties and widen the scope of potential applications, is of considerable interest. Here, we report the synthesis of new anionic alkyl glycosides with long carbohydrate chains, using two different approaches: laccase/TEMPO oxidation of a long‐carbohydrate‐chain alkyl glycoside, and cyclodextrin glucanotransferase (CGTase)‐catalysed elongation of

Missions are being discussed widely within the European Union and beyond as a tool to steer policy, innovation, and research. Similar to other missions – to the moon, to cure cancer, and to eradicate smallpox – the missions-oriented approach seeks to set bold and radical goals to tackle our pressing environmental and social challenges. In this episode, we discuss the missions-oriented approach forMissions are being discussed widely within the European Union and beyond as a tool to steer policy, innovation, and research. Similar to other missions – to the moon, to cure cancer, and to eradicate smallpox – the missions-oriented approach seeks to set bold and radical goals to tackle our pressing environmental and social challenges. In this episode, we discuss the missions-oriented approach for

AbstractPurpose – For non-profit organizations (NPOs) external funding is an essential resource. Studies highlight how control is attributed to funders and so external funding threatens the autonomy of the recipient organization. The purpose of this study is to investigate how external control can be structured and exercised,and to explore how control interacts with organizational autonomy.Design/

We use energy in almost every aspect of our lives. Yet, often, we do not know the source of electricity that powers our homes or heats our food. In this episode, we explore energy communities as a form of decentralised and democratic energy production. Community energy sees people coming together to take control of their energy needs, by finding alternative ways to organise and govern the energy sWe use energy in almost every aspect of our lives. Yet, often, we do not know the source of electricity that powers our homes or heats our food. In this episode, we explore energy communities as a form of decentralised and democratic energy production. Community energy sees people coming together to take control of their energy needs, by finding alternative ways to organise and govern the energy s

If we want to imagine a more sustainable future, we need to be emotionally connected with that vision. Providing the latest facts and figures alone won’t do the trick. We suggest storytelling can be a great way to convey these facts in a compelling way to envision and connect with a possible future. Stories are an effective narrative device, because they activate areas of the brain responsible for

Sustainable finance, non-financial disclosures, ESG, oh my! The world of sustainable finance may seem dark and scary. But, in this episode, we introduce many key concepts through dialogue as well as discuss how sustainable finance contributes to wider sustainability objectives. The finance sector is playing an ever growing role in supporting the transition to a Paris-aligned world by incorporating