The first syntheses of the isomeric dioxafenestrene natural products (-)-asperaculin A and (-)-penifulvin D are reported. Each target is formed selectively by choice of oxidant in a final divergent bioinspired Baeyer-Villiger (BV) reaction. Density functional theory calculations reveal that electrostatic interactions between the oxidant leaving group and the lactone motif accounts for a reversal o

Abstract: Soft and biological materials are often composed of elementary constituents exhibiting an incessant roto-translational motion at the microscopic scale. Tracking this motion with a bright-field microscope becomes increasingly challenging when the particle size becomes smaller than the microscope resolution, a case which is frequently encountered. Here we demonstrate squared-gradient diffe

Major low-latitude volcanic eruptions cool Earth’s climate, and can lead to a positive phase of the North Atlantic Oscillation (NAO) during winter. However, the question of the climate and circulation impact of Northern Hemisphere high-latitude eruptions has received less attention. Here we show that, contrary to low-latitude eruptions, the response to high-latitude eruptions can be associated wit

Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 and November 20, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were pre

Ecologists and evolutionary biologists are well aware that natural and sexual selection do not operate on traits in isolation, but instead act on combinations of traits. This long-recognized and pervasive phenomenon is known as multivariate selection, or—in the particular case where it favours correlations between interacting traits—correlational selection. Despite broad acknowledgement of correla

The annual growth cycle of boreal trees is synchronized with seasonal changes in photoperiod and temperature. A warmer climate can lead to an earlier bud burst and increased risk of frost damage caused by temperature backlashes. In this study we analysed site- and provenance specific responses to interannual variation in temperature, using data from 18 Swedish and East-European provenances of Norw

This thesis takes an interest in newer forms of contract-based dispute resolution used in commercial disputes. Public civil trial and arbitration has for a long time been the procedure of choice for disputing commercial parties. Arbitration is still by far the most established and used procedure when it comes to private dispute resolution. However, for some decades, newer forms of private procedurThis thesis takes an interest in newer forms of contract-based dispute resolution used in commercial disputes. Public civil trial and arbitration has for a long time been the procedure of choice for disputing commercial parties. Arbitration is still by far the most established and used procedure when it comes to private dispute resolution. However, for some decades, newer forms of private procedur

Rationale & Objective: Chronic kidney disease (CKD) is a global health problem with increasing prevalence. Several sex-specific differences have been reported for disease progression and mortality. Selection and survival bias might have influenced the results of previous cohort studies. The objective of this study was to investigate sex-specific differences of CKD progression and mortality amo

Denna studie kretsar kring pheriwale, en grupp egenföretagare inom Indiens stora informella ekonomi. Pheriwale har livnärt sig på handel i Delhi under nästan ett sekel och sysslar med handel med begagnade kläder. De är en av de mest tydligt kvinnodominerade grupperna av gatuhandlare och -försäljare i staden. Genom att knacka dörr hos invånare i staden och förorten sysslar de med byteshandel och saThis study revolves around the working lives of pheriwale, a group of self-employed traders within India’s vast informal economy. Pheriwale have been trading in Delhi for nearly a century and are involved in the second-hand clothing trade. Among the wide variety of street vendors and traders in the city, pheriwale are one of the most visibly women-dominated. They offer a door-to-door service, coll

Recension/anmeldelse af Tine Aagaard & Lise Hounsgaard (red.) Menneske – sundhed, samfund og kultur Forlaget Klim 2020, 412 sider – 349,95 kr.

The clinical presentation of Alzheimer's disease (AD) varies widely across individuals but the neurobiological mechanisms underlying this heterogeneity are largely unknown. Here, we compared regional gray matter (GM) volumes and associated gene expression profiles between cognitively-defined subgroups of amyloid-β positive individuals clinically diagnosed with AD dementia (age: 66 ± 7, 47% male, M

Fungi and bacteria are the two principal microbial groups in soil, responsible for the breakdown of organic matter (OM). The relative contribution of fungi and bacteria to decomposition is thought to impact biogeochemical cycling at the ecosystem scale, whereby bacterially dominated decomposition supports the fast turnover of easily available substrates, whereas fungal-dominated decomposition lead

Background: Pathology in the noradrenergic A6 locus coeruleus has not been compared with more rostral dopaminergic A9 substantia nigra and A10 ventral tegmental area, and cholinergic Ch4 basal nucleus and Ch1/2 septal regions in the same cases of Parkinson's disease (PD). Objective: To determine whether there is a gradient of caudal to rostral cell loss in PD. Methods: Postmortem brains were colle

We utilize perspectives in environmental sociology and politicaleconomy to examine relationships between human exploitationand ecological degradation. Specifically, we apply global laborvalue chains and the tragedy of the commodity to analyze severelabor exploitation in Thai capturefisheries. Our analysis suggeststhat severe labor exploitation has played a significant role inlowering the market va

BACKGROUND: In adult patients with pulmonary arterial hypertension (PAH), right ventricular (RV) failure may worsen rapidly, resulting in a poor prognosis. In this population, non-invasive assessment of RV function is challenging. RV stroke work index (RVSWI) measured by right heart catheterization (RHC) represents a promising index for RV function. The aim of the present study was to comprehensiv

A measurement of the Bs0→J/ψϕ decay parameters using 80.5fb-1 of integrated luminosity collected with the ATLAS detector from 13 Te proton–proton collisions at the LHC is presented. The measured parameters include the CP-violating phase ϕs, the width difference Δ Γ s between the Bs0 meson mass eigenstates and the average decay width Γ s. The values measured for the physical parameters are combined

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles (SV) and released at the synaptic active zone (AZ). While in recent years major progress has been made in unraveling the molecular machinery responsible for SV docking, fusion and exocytosis, the mechanisms governing AZ protein and SV trafficking through axons still remain unclear. Here, we performed stop-f