Subcellular localization of protein kinase often plays an important role in determining its activity and specificity. Protein kinase C (PKC), a family of multi-gene protein kinases has long been known to be translocated to the particular cellular compartments in response to DAG or its analog phorbol esters. We used C-terminal green fluorescent protein (GFP) fusion proteins of PKC isoforms to visua

BACKGROUND: In order to determine myocardial salvage, accurate quantification of myocardium at risk (MaR) is necessary. We present a validated novel automatic segmentation algorithm for quantification of MaR by myocardial perfusion SPECT (MPS) in patients with acute coronary occlusion. METHODS AND RESULTS: Twenty-nine patients with coronary occlusion were injected with a perfusion tracer before re

Objectives. During the past decade, the position of biologics in the therapeutic armamentarium, the number of approved indications and the number of available biologics have changed. Available data on (long-term) safety might thus pertain to patient populations not comparable with contemporary patients. The aim of this study was to assess the extent to which contemporary patients who start or swit

Summary: Traditionally, fire safety has often been addressed with methods based on prescriptive recommendations. The opportunity to use an alternative analytical approach has led to the development of fire safety engineering, beginning with structural fire safety design in the 1960's and today including fire safety design and fire risk analysis in general. The prediction of reality using model cal

While Lars Norén’s confrontational and self-exposing En dramatikers dagbok (A Dramatist’s Journal, 2008) already has spurred discussions on the nature of confession in today’s mediatised literary public sphere, less has been said about the aesthetic project of the journal. By tracing this project back to Norén’s poetry of the 1960s as well as by comparing it to works by Lyn Hejinian and Kenneth Go

This article builds on the recognizition that the declining child sex ratios in rural India are a result of an ongoing process of social change. It looks at areas both in the north and in the south which have shown significant decline in the child sex ratio between 1991 and 2001. In order to understand why the lives of female children are at risk and why there is an increasing discrimination again

In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluati

Scattering from an acoustically soft elliptic disk is treated by means of the null field approach. It is shown that in the disk limit of a general ellipsoid the relevant matrix elements have a well-defined limit, and that the formulation is attractive for numerical calculations. In a separate section the low frequency expressions of the total cross section and the far field amplitude are also deri

This article is a review of a book by the Swedish ethnologist Billy Ehn. The book gives a description and analysis of the events when four departments were integrated into one. The writing of the book resulted in a conflict that forced Ehn to resign as the dean of the newly created department. One reason for his resignation was that the staff of the department felt that they had not been properly

The role of Latin in the formation of Western Europe, especially through the Carolingian Reform and the medieval University.